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Mithun Sinha, Ph.D.

Assistant Professor of Surgery

Presentation: Breast Implant Biofilm Mediated Immune Response




Dr. Sinha currently serves as Assistant Professor of Surgery at Indiana University School of
Medicine. He received his doctoral degree in Biotechnology from University of Calcutta, India.
Prior to joining Indiana University, Dr. Sinha did his post-doctoral training at The Ohio State
University, Columbus, Ohio. His laboratory is investigating immunological manifestations
mediated by implant-associated bacterial biofilm. The research focuses on breast and
orthopedic implants. He collaborates with surgeons in the division of plastic surgery, department
of orthopedic surgery, Indiana University school of medicine and community plastic surgeons to
address this problem. His laboratory is primarily funded through grants from NIH/NIAID. He has
more than 30 peer reviewed publications.

Key Publications:


  1. Suh LJ, Khan I, Kelley-Patteson, C, Mohan G, Hassanein, AH, Sinha M. Breast Implant Associated Immunological Disorders. Journal of Immunology Research DOI: 10.1155/2022/8536149.


  1. Sinha M*, Ghosh N, Wijesinghe DS, Mathew-Steiner SS, Das A, Singh K, El Masry M, Khanna S, Inoue H, Yamazaki K, Kawada M, Gordillo GM, Roy S, Sen CK*. Pseudomonas aeruginosa Theft Biofilm Require Host Lipids of Cutaneous Wound. Annals of Surgery doi: 10.1097/SLA.0000000000005252 (*co-corresponding authors).


  1. Sinha M, Sen CK, Singh K, Das A, Ghatak S, Rhea B, Blackstone B, Powell H, Khanna S, Roy S. Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue. Nature Communications 2018; 9 (1): 936. DOI:10.1038/s41467-018-03208-w


  1. Singh K, Sinha M, Pal D, Tabasum S, Gnyawali SC, Kona D, Sarkar S, Mohanty SK, Soto-Gonzalez F, Khanna S, Roy S, Sen CK. Cutaneous epithelial to mesenchymal transition activator ZEB1 regulates wound angiogenesis and closure in a glycemic status dependent manner. Diabetes 2019, Nov;68(11):2175-2190. DOI: 10.2337/db19-0202


  1. Gallego-Perez D, Pal D, Ghatak S, Malkoc V, Higuita-Castro N, Gnyawali S, Chang L, Liao W, Shi J, Sinha M, Singh K, Steen E, Sunyecz A, Stewart R, Moore J, Ziebro T, Northcutt R, Homsy M, Bertani P, Lu W, Roy S, Khanna S, Rink C, Sundaresan V, Otero J, Lee LJ, Sen CK. Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue. Nature Nanotechnology 2017; 12 (10), 974-979. DOI: 10.1038/nnano.2017.134


  1. Das A*, Sinha M*, Datta S, Abas M, Chaffee S, Sen CK, Roy S. Monocyte and macrophage plasticity in tissue repair and regeneration. The American Journal of Pathology 2015, 185 (10), 2596-2606. (* joint first authors)

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